受体缺乏改变小鼠脑内组胺含量及昼夜节律

在乙谜麻醉下,分别于明时(8:00 a.m.)及暗时(8:00 p.m.)断头处死野生型及组胺H1R基因敲除型小鼠,迅速取出脑组织并分离出皮层、纹状体、海马、下丘脑、丘脑、中脑及脑干等脑区.这些脑组织被制成匀浆并用HPLC荧光检测法测量其组胺含量.结果显示暗时处死时,H1R基因敲除型小鼠海马、丘脑、中脑及脑干中的组胺含量明显低于野生型小鼠.明时处死时,野生型小鼠各脑区组胺含量均较暗时处死显著降低,但这一变化在H1R基因敲除型小鼠中并未观察到.这些表明作为组胺的功能靶,H1R不仅介导组胺的功能,而且调节大脑中组胺含量与释放的昼夜节律.     

研究简报(Nd_(1-x)Er_x)_3 Fe_(27.31)Ti_(1.69)化合物的磁晶各向异性

用振动样品磁强计并结合X射线衍射准确判定了Nd2.4Er0.6Fe27.31Ti1.69化合物的磁晶各向异性方式,研究结果发现,Nd2.4Er0.6Fe27.31Ti1.69化合物的磁晶各向异性从室温时的易面转变到低温时的易锥.     

Fine three-dimensional P-wave velocity structure beneath the capital region and deep environment for the nucleation of strong earthquakes

A detailed 3-D P-wave velocity model of the crust and uppermost mantle under the capitol region is determined with a spatial resolution of 25 km in the horizontal direction and 4-17 km in depth. We used 48750 precise P-wave arrival time data from 2973 events of local crustal earthquakes, controlled seismic explosions and quarry blasts. These events were recorded by 123 seismic stations. The data are analyzed by using a 3-D seismic tomography method. Our tomographic model provides new information on the geological structure and complex seismotectonics of this region. Different patterns of velocity structures show up in the North China Basin, the Taihangshan and the Yanshan Mountainous areas. The velocity images of the upper crust reflect well the surface geological, topographic and lithological features. In the North China Basin, the depression and uplift areas are imaged as slow and fast velocity belts, respectively, which are oriented in NE-SW direction. The trend of velocity anomalies is the same as that of major structure and tectonics. Paleozoic strata and Pre-Cambrian basement rocks outcrop widely in the Taihangshan and Yanshan uplift areas, which exhibit strong and broad high-velocity anomalies in our tomographic images, while the Quaternary intermountain basins show up as small low-velocity anomalies. Most of large earthquakes, such as the 1976 Tangshan earthquake (M 7.8) and the 1679 Sanhe earthquake (M 8.0), generally occurred in high-velocity areas in the upper to middle crust. However, in the lower crust to the uppermost mantle under the source zones of the large earthquakes, low-velocity and high-conductivity anomalies exist, which are considered to be associated with fluids, just like the 1995 Kobe earthquake (M 7.2) and the 2001 Indian Bhuj earthquake (M 7.8). The fluids in the lower crust may cause the weakening of the seismogenic layer in the upper and middle crust and thus contribute to the initiation of the large crustal earthquakes.     

Bi熔体粘滞性的非连续变化现象

金属熔体的粘滞性是液态金属原子迁移能力的一种表现，反映了原子间结合力的大小，是重要的熔体敏感物理性质之一，从中能得到许多关于液态结构的信息，同时也是重要的铸造工艺参数。Bi熔体的粘度一温度曲线关系表明，粘度随着温度的降低而增加，但并不连续，计算可知，高温区域的粘流活化能E值最小，低温区域的最大，中温区域的处于两者之间。随温度升高，流团尺寸vm在减小。结合DSC曲线分析认为，粘度异常变化区域是Bi熔体由不均匀向均匀原子结构非连续变化所引起的，与熔体中原子健的转变密切相关。     

ThSiO4晶体中Yb^3＋离子的自旋哈密顿参量的理论研究

从晶体场理论出发，用考虑了二阶微扰贡献的理论公式和由晶体结构数据和重叠模型获得的晶场参量，计算了ThSiO4晶体中四角对称的Yb^3 离子的自旋哈密顿参量g因子和超精细结构常数A因子，计算结果与实验很好地符合，并对结果进行了讨论。     

基于嵌入式系统的音频点播系统

介绍一种基于嵌入式系统的C／S结构音频点播系统，它将MP3音频文件集中存储在网络服务器上，利用自主开发的MP3播放终端进行网络点播，并重点介绍基于uClinux的嵌入式MP3播放终端的设计。这种音频点播系统可以广泛应用在卡拉OK厅、语音教室和公共广播等许多场所。     

移动通信技术W-CDMA技术分析

文章着重介绍了3G技术的代表W-CDMA系统及其关键技术。通过分析GSM、W-CDMA在覆盖与容量、及核心网之间的差异,重点突出了3G技术的在移动数据承载能力,指明了2.5G技术在承载能力和业务实现的局限性。最后本文对移动通信技术的未来做了一些简单的总结,提出了一些个人的见解。     

长效H2受体拮抗剂-拉呋替丁的合成

以2-溴-4-(哌啶基甲基)吡啶为原料,与2-丁烯-1,4-二醇醚化,经氯化、G abrie l反应、肼解,然后再与2-呋喃甲硫基-S-氧代乙酸对硝基苯酚酯进行胺解反应,制得第二代长效H2受体拮抗剂拉呋替丁,总收率为29.89%[以2-溴-4-(哌啶基甲基)吡啶计]。     

以芳胺为端基的酰胺型开链冠醚及其配合物的合成与表征

以对硝基苯胺和对甲基苯胺二种芳胺为端基合成了6种酰胺型开链冠醚,通过IR,1HNMR及MS确定了它们的结构,同时用N,N'-二(对硝基苯胺)-3-氧杂戊二酰胺为配体与轻稀土硝酸盐进行了配位研究,合成了5种轻稀土硝酸盐配合物,通过元素分析和IR分析了其结构.     

H.323系统在会议电视中的应用

介绍了会议电视系统的组成,着重论述了H.323系统的协议控制以及在会议电视系统中的应用。